Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica leave aqueous extract (C. asiatica) (50, 100, and 200 mg/kg/b.w.) were given to diabetic rats for 28 days. Changes in rats’ body weight, food and water intakes, and insulin and FBG levels were monitored. Following sacrificed, cerebrum was harvested and subjected for histological, biochemical, and molecular biological analyses. The results revealed treatment with C. asiatica was able to ameliorate the loss in body weight, the increase in food and water intakes, the decrease in insulin, and the increase in FBG levels in diabetic rats. Additionally, histopathological changes in the cerebrum and levels of p38, ERK, JNK, cytosolic Nrf2, Keap-1, LPO, RAGE, and AGE levels decreased; however, PI3K, AKT, IR, IRS, GLUT-1, nuclear Nrf_2,Nqo-1, Ho-1, and anti-oxidative enzymes (SOD, CAT, and GPx) levels increased in diabetic rats receiving C. asiatica. Furthermore, C. asiatica treatment also caused cerebral inflammation and apoptosis to decrease as indicated by decreased inflammatory markers (cytosolic NF-κB p65, p-Ikkβ, Ikkβ, iNOS, COX-2, TNF-α, IL-6, and IL-1β), decreased pro-apoptosis markers (Casp-3, 9, and Bax), but increased anti-apoptosis marker, Bcl-2. Activity level of Na⁺/K⁺, Mg²⁺, and Ca²⁺-ATPases in the cerebrum also increased by C. asiatica treatment. Conclusions: C. asiatica treatment helps to prevent cerebral damage and maintain near normal cerebral function in diabetes.

据称积雪草具有神经保护作用。但是，尚未发现其保护大脑免受糖尿病损害的能力。目的是确定亚洲隐孢子虫改善糖尿病大脑炎症，氧化应激和细胞凋亡的可能性。对糖尿病大鼠给予积雪草叶子含水提取物（积雪草）（50、100和200mg / kg / bw）28天。监测大鼠体重，食物和水的摄入量以及胰岛素和FBG水平的变化。处死后，收获大脑并进行组织学，生化和分子生物学分析。结果显示用亚洲隐孢子虫治疗能够减轻糖尿病大鼠的体重减轻，食物和水摄入量的增加，胰岛素的减少以及FBG水平的增加。此外，大脑的组织病理学变化和p38，ERK，JNK，胞浆Nrf2，Keap-1，LPO，RAGE和AGE水平下降；但是，在接受亚洲隐孢子虫的糖尿病大鼠中，PI3K，AKT，IR，IRS，GLUT-1，核Nrf _2，Nqo -1，Ho-1和抗氧化酶（SOD，CAT和GPx）的水平增加。此外，C。asiatica炎症标记物减少（胞浆NF-κBp65，p-Ikkβ，Ikkβ，iNOS，COX-2，TNF-α，IL-6和IL-1β）表明，治疗还导致脑部炎症和细胞凋亡减少。 -凋亡标记物（Casp-3、9和Bax），但抗凋亡标记物Bcl-2增加。的Na的活动水平⁺ / K ⁺，Mg的²⁺和Ca ²⁺在大脑-ATP酶也增加了积雪草治疗。结论：积雪草治疗有助于预防糖尿病的脑损伤并维持接近正常的脑功能。