High consumption of drugs, combined with their presence in the environment, raises concerns about its consequences. Even though researches are often engaged in analyzing substances separately, that is not the environmental reality. Therefore, the aim of this study was to investigate the acute toxicity of the pharmaceuticals simvastatin, metformin, omeprazole and diazepam, and all possible mixtures between them, to the organism Aliivibrio fischeri, verifying possible synergistic or antagonistic effects and assessing byproducts formation. In terms of individual toxicity, omeprazole is the most toxic of the active ingredients, followed by simvastatin, diazepam and, finally, metformin. When the toxicity of mixtures was tested, synergism, antagonism and hormesis were perceived, most probably generated due to byproducts formation. Moreover, it was observed that even when compounds are at concentrations below the non-observed effect concentration (NOEC), there may be toxicity to the mixture. Hence, this work points to the urgent need for more studies involving mixtures, since chemicals are subject to interactions and modifications, can mix, and potentiate or nullify the toxic effect of each other

毒品的大量消费，再加上它们在环境中的存在，引起了人们对其后果的担忧。即使研究经常单独进行物质分析，但这并不是环境现实。因此，本研究的目的是研究辛伐他汀，二甲双胍，奥美拉唑和地西epa以及它们之间所有可能的混合物对费氏阿利博韦氏菌的急性毒性。，验证可能的协同作用或拮抗作用，并评估副产物的形成。就个人毒性而言，奥美拉唑是活性成分中毒性最高的，其次是辛伐他汀，地西epa，最后是二甲双胍。当测试混合物的毒性时，可以观察到协同作用，拮抗作用和兴奋作用，很可能是由于副产物的形成而产生的。此外，已观察到即使化合物的浓度低于未观察到的作用浓度（NOEC），对混合物也可能有毒性。因此，这项工作表明迫切需要对混合物进行更多的研究，因为化学物质易受相互作用和修饰的影响，可以相互混合并增强或消除彼此的毒性作用。