Background EBV produces miRNAs with important functions in cancer growth, tumor invasion and host immune surveillance. The discovery of EBV miR-BARTs is recent, and most of their functions are still unknown. Nonetheless, some new studies underline their key roles in EBV-associated malignancies. Main body In EBV-associated tumors, the expression profile of miR-BARTs varies according to the cell type, autophagic process and signals received from the tumor microenvironment. By the same way of interest is the interaction between tumor cells and the tumor environment by the release of selected EBV miR-BARTs in addition to the tumor proteins trough tumor exosomes. Conclusion In this review, we discuss new findings regarding EBV miR-BARTs in Hodgkin lymphoma and gastric cancer. The recent discovery that miRNAs are released by exosomes, including miR-BARTs, highlights the importance of tumor and microenvironment interplay with more specific effects on the host immune response.

中文翻译：

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EBV 相关霍奇金淋巴瘤和胃癌中的 Epstein-Barr 病毒 BART microRNA

背景 EBV 产生的 miRNA 在癌症生长、肿瘤侵袭和宿主免疫监视中具有重要作用。EBV miR-BARTs 的发现是最近才发现的，它们的大部分功能仍然未知。尽管如此，一些新的研究强调了它们在 EBV 相关恶性肿瘤中的关键作用。主体 在 EBV 相关肿瘤中，miR-BARTs 的表达谱因细胞类型、自噬过程和从肿瘤微环境中接收到的信号而异。同样令人感兴趣的是肿瘤细胞与肿瘤环境之间的相互作用，除了通过肿瘤外泌体释放肿瘤蛋白外，还通过释放选定的 EBV miR-BART。结论 在这篇综述中，我们讨论了有关 EBV miR-BARTs 在霍奇金淋巴瘤和胃癌中的新发现。最近发现 miRNA 由外泌体释放，