Mitochondrion-targeting chemiluminescent ternary supramolecular assembly for in situ photodynamic therapy.,Chemical Communications

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Mitochondrion-targeting chemiluminescent ternary supramolecular assembly for in situ photodynamic therapy.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-06-24 , DOI: 10.1039/d0cc01868f
Lei Chen ₁ , Yong Chen , Weilei Zhou , Jingjing Li , Yi Zhang , Yu Liu

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The development of smart supramolecular self-assemblies for photodynamic therapy (PDT) and organelle-targeting cell imaging has become a hot topic of research due to their rapid and intelligent responses. Herein, we report a novel ternary supramolecular assembly of nanoparticles, composed specifically of photosensitizer molecules 4,4′-(dibenzo[a,c]phenazine-9,14-diyl)pyridin-1-ium bromide (DPAC-S) and cucurbit[7]uril (CB[7]) co-assembled with bis[2,4,5-trichloro-6-(pentyloxycarbonyl)phenyl]oxalate (CPPO). Overexpressed hydrogen peroxide in tumor cells was used to rapidly stimulate these nanoparticles to produce chemiluminescence and simultaneously sensitize oxygen molecules to singlet oxygen (¹O₂) for in situ PDT. A cell imaging experiment further confirmed the ability of the nanoparticle assembly to effectively target mitochondria, a feature beneficial for enhancing PDT.

中文翻译：

线粒体靶向化学发光三元超分子组装的原位光动力疗法。

用于光动力疗法（PDT）和细胞器靶向细胞成像的智能超分子自组装体的开发由于其快速和智能的响应而成为研究的热点。在这里，我们报告纳米粒子的新型三元超分子组装，具体由光敏剂分子4,4'-（二苯并[ a，c ]吩嗪-9,14-二基）吡啶-1-溴化铵（DPAC-S）和葫芦组成[7]尿素（CB [7]）与双[2,4,5-三氯-6-（戊氧基羰基）苯基]草酸酯（CPPO）共组装。肿瘤细胞中过表达的过氧化氢用于快速刺激这些纳米颗粒以产生化学发光，并同时使氧分子对单线态氧（¹ O ₂）敏感。太平洋夏令时。细胞成像实验进一步证实了纳米颗粒组件有效靶向线粒体的能力，线粒体是有益于增强PDT的功能。

更新日期：2020-08-04

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