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Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-06-23 , DOI: 10.1039/d0bm00860e Benjamin M Richardson 1 , Cierra J Walker , Laura J Macdougall , Jack W Hoye , Mark A Randolph , Stephanie J Bryant , Kristi S Anseth
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-06-23 , DOI: 10.1039/d0bm00860e Benjamin M Richardson 1 , Cierra J Walker , Laura J Macdougall , Jack W Hoye , Mark A Randolph , Stephanie J Bryant , Kristi S Anseth
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Chondrocyte deformation influences disease progression and tissue regeneration in load-bearing joints. In this work, we found that viscoelasticity of dynamic covalent crosslinks temporally modulates the biophysical transmission of physiologically relevant compressive strains to encapsulated chondrocytes. Chondrocytes in viscoelastic alky-hydrazone hydrogels demonstrated (91.4 ± 4.5%) recovery of native rounded morphologies during mechanical deformation, whereas primarily elastic benzyl-hydrazone hydrogels significantly limited morphological recovery (21.2 ± 1.4%).
中文翻译：
腙交联聚乙二醇水凝胶的粘弹性在机械变形过程中指导软骨细胞形态。
软骨细胞变形影响承重关节的疾病进展和组织再生。在这项工作中，我们发现动态共价交联的粘弹性暂时调节生理相关压缩应变向封装软骨细胞的生物物理传递。粘弹性烷基腙水凝胶中的软骨细胞在机械变形过程中表现出（91.4±4.5%）天然圆形形态的恢复，而主要弹性苄基腙水凝胶显着限制了形态恢复（21.2±1.4%）。
更新日期：2020-07-14
中文翻译：
腙交联聚乙二醇水凝胶的粘弹性在机械变形过程中指导软骨细胞形态。
软骨细胞变形影响承重关节的疾病进展和组织再生。在这项工作中，我们发现动态共价交联的粘弹性暂时调节生理相关压缩应变向封装软骨细胞的生物物理传递。粘弹性烷基腙水凝胶中的软骨细胞在机械变形过程中表现出（91.4±4.5%）天然圆形形态的恢复，而主要弹性苄基腙水凝胶显着限制了形态恢复（21.2±1.4%）。
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