Development of T₁/T₂ dual-mode MRI contrast agents that can also treat cancer is an attractive prospect for personalized precision medicine. Unfortunately, conventional contrast agents can suffer from toxicity and lack any ability to treat cancer. An all-iron T₁/T₂ MR imaging agent with photothermal and drug delivery capability would overcome these issues. Here, an avocado-like Fe³⁺/Fe₂O₃ composed T₁-T₂ dual-mode contrast agent based on Fe-TA coordination network (CNMN) is developed. This material possesses suitable longitudinal and transverse relaxation coefficients. Moreover, the strong heat generation property of Fe-TA endows CNMN with the capability to act as a potent photothermal agent. Furthermore, CNMN can also act as an effective delivery platform for the chemotherapeutic drug doxorubicin (DOX) to achieve high effective chemo-photothermal combination therapy. The work demonstrates reliable T₁-T₂ MRI-guided chemo-photothermal therapy for safe and effective clinical application.

中文翻译：

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双模鳄梨状全铁纳米平台，用于增强的T1 / T2 MRI指导的癌症治疗学治疗。

可以治疗癌症的T ₁ / T ₂双模MRI造影剂的开发对于个性化精密医学有着诱人的前景。不幸的是，常规的造影剂会遭受毒性并且缺乏任何治疗癌症的能力。具有光热和药物输送能力的全铁T ₁ / T ₂ MR成像剂将克服这些问题。在此，鳄梨状的Fe ³⁺ / Fe ₂ O ₃组成T ₁ -T ₂开发了基于Fe-TA配位网络（CNMN）的双模造影剂。该材料具有合适的纵向和横向弛豫系数。此外，Fe-TA的强生热特性使CNMN能够用作有效的光热剂。此外，CNMN还可以充当化学治疗药物阿霉素（DOX）的有效递送平台，以实现高效的化学-光热联合疗法。这项工作证明了可靠的T ₁ -T ₂ MRI引导的化学光热疗法可安全有效地应用于临床。