Background. Obesity is related to coronary artery disease (CAD) and worse outcomes in coronary artery bypass graft (CABG) patients. Adipose tissue itself is an endocrine organ that secretes many humoral mediators, such as adipokines, which can induce or reduce inflammation and oxidative stress. Objectives. We investigate the relationship between the body mass index (BMI), inflammation, and oxidative stress by measuring serum levels of leptin, interleukin-6, and 3-nitrotyrosine in CABG patients and correlate their levels to the cardiovascular and operative risk profiles. Methods and Results. 45 men (<75 years) with a median BMI of 29 (21-51) kg/m², who were diagnosed with CAD and scheduled for elective CABG, were included after applying the following exclusion criteria: prior myocardial infarction, reoperation, female gender, and smoking. Patients’ blood samples were taken preoperatively. Several markers were measured. We found significant correlations between leptin and BMI as well as between leptin and 3-nitrotyrosine . Interleukin-6 was correlated with C-reactive protein and with the incidence of insulin-dependent diabetes mellitus , arterial hypertension , reduced left ventricular function , and severe coronary calcification . It was also associated with significantly longer extracorporeal bypass time . Postoperative deep sternal wound infections could be predicted by a higher BMI and leptin level . Conclusions. There seems to be a correlation between inflammatory processes and cardiovascular morbidity in our cohort. Further, the incidence of deep sternal wound infections is related to a higher BMI and leptin serum level.

中文翻译：

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体重指数 (BMI) 及其对冠状动脉搭桥移植患者心血管和手术风险状况的影响：炎症和瘦素的影响。

背景。肥胖与冠状动脉疾病 (CAD) 和冠状动脉搭桥术 (CABG) 患者的不良预后有关。脂肪组织本身是一种内分泌器官，可分泌许多体液介质，如脂肪因子，可诱导或减轻炎症和氧化应激。目标。我们通过测量 CABG 患者的血清瘦素、白细胞介素 6 和 3-硝基酪氨酸水平来研究体重指数 (BMI)、炎症和氧化应激之间的关系，并将它们的水平与心血管和手术风险概况相关联。方法和结果。45 名男性（<75 岁），中位 BMI 为 29 (21-51) kg/m ²被诊断患有 CAD 并计划进行选择性 CABG 的患者在应用以下排除标准后被纳入：既往心肌梗塞、再次手术、女性和吸烟。术前采集患者血样。测量了几个标记。我们发现瘦素和BMI之间存在显着相关性以及瘦素和 3-硝基酪氨酸之间. 白细胞介素6与C反应蛋白相关和胰岛素依赖型糖尿病的发病率,高血压,降低左心室功能，以及严重的冠状动脉钙化. 它还与显着更长的体外旁路时间有关. 较高的BMI可以预测术后深部胸骨伤口感染和瘦素水平. 结论。在我们的队列中，炎症过程和心血管发病率之间似乎存在相关性。此外，深部胸骨伤口感染的发生率与较高的 BMI 和瘦素血清水平有关。