This work deals with oxygenated apatite synthesis from calcium chloride and phosphoric acid using a wet precipitation method. An experimental design is applied to precise the influence of the synthesis parameters (pH of the reaction medium, atomic ratio Ca/P of the reagents, concentration of the calcium solution (Ca²⁺), temperature of the reaction medium (T), and duration of the reaction (D)) on the chemical composition (Ca/P molar ratio, % O₂, and ). An empirical model was developed and validated by applying the ANOVA analysis incorporating the interaction effects of all parameters and optimized using the response surface methodology. A reproducible synthesis of more oxygenated apatite with speed of dissolution adaptable to that of the osseous neoformation and allowing a progressive diffusion of oxygenated species (Ca/P = 1.575) is attained.

中文翻译：

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统计实验设计和表面绘图技术在优化氧化磷灰石合成中的应用

这项工作涉及使用湿式沉淀法由氯化钙和磷酸合成氧化磷灰石。通过实验设计可以精确地影响合成参数（反应介质的pH，试剂的原子比Ca / P，钙溶液的浓度（Ca ²⁺），反应介质的温度（T））的影响。反应时间（D））的化学组成（Ca / P摩尔比，％O ₂和）。通过应用ANOVA分析并结合所有参数的相互作用效应，开发并验证了经验模型，并使用响应面方法进行了优化。获得了可再生的更多含氧磷灰石的合成方法，其溶解速度适应于骨新形成反应的溶解速度，并允许含氧物质逐步扩散（Ca / P = 1.575）。