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Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite Synthesis
Advances in Materials Science and Engineering Pub Date : 2020-06-24 , DOI: 10.1155/2020/1034959
Soumia Belouafa 1 , Hassan Chaair 2 , Khalid Digua 2
Affiliation  

This work deals with oxygenated apatite synthesis from calcium chloride and phosphoric acid using a wet precipitation method. An experimental design is applied to precise the influence of the synthesis parameters (pH of the reaction medium, atomic ratio Ca/P of the reagents, concentration of the calcium solution (Ca2+), temperature of the reaction medium (T), and duration of the reaction (D)) on the chemical composition (Ca/P molar ratio, % O2, and ). An empirical model was developed and validated by applying the ANOVA analysis incorporating the interaction effects of all parameters and optimized using the response surface methodology. A reproducible synthesis of more oxygenated apatite with speed of dissolution adaptable to that of the osseous neoformation and allowing a progressive diffusion of oxygenated species (Ca/P = 1.575) is attained.

中文翻译:

统计实验设计和表面绘图技术在优化氧化磷灰石合成中的应用

这项工作涉及使用湿式沉淀法由氯化钙和磷酸合成氧化磷灰石。通过实验设计可以精确地影响合成参数(反应介质的pH,试剂的原子比Ca / P,钙溶液的浓度(Ca 2+),反应介质的温度(T))的影响。反应时间(D))的化学组成(Ca / P摩尔比,%O 2)。通过应用ANOVA分析并结合所有参数的相互作用效应,开发并验证了经验模型,并使用响应面方法进行了优化。获得了可再生的更多含氧磷灰石的合成方法,其溶解速度适应于骨新形成反应的溶解速度,并允许含氧物质逐步扩散(Ca / P = 1.575)。
更新日期:2020-06-24
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