Functional Hybrid Glyconanocapsules by a One-Pot Nanoprecipitation Process.,Biomacromolecules

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Functional Hybrid Glyconanocapsules by a One-Pot Nanoprecipitation Process.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-06-24 , DOI: 10.1021/acs.biomac.0c00697
Xibo Yan ₁ , Pierre Alcouffe ₂ , Julien Bernard ₂ , François Ganachaud ₂

Affiliation

Herein, we report on one-pot fabrication of oil-filled nanocapsules wrapped with both RAFT-made glycopolymers and neutral polysaccharides (dextran and pullulan). We have made use of the nanoprecipitation technique, relying on coprecipitation of both oil and polymers in conditions thoroughly established from phase diagrams’ interpretation. Mixed mono- or multilayered nanocapsules were obtained through simultaneous or sequential nanoprecipitations, respectively. Incorporation of synthetic glycopolymer chains allows for precisely tailoring the dimensions of the nanocapsules (size and membrane thickness of the polymeric shell), whereas the insertion of polysaccharides enables to tune the (bio)degradability of the nanocapsules. Shell-functionalized and/or core-loaded capsules could also be achieved in a similar one-pot process, by introducing a drug and/or biotin in the organic and aqueous phase, respectively.

中文翻译：

一锅纳米沉淀法制备的功能性混合型糖醇胶囊。

在此，我们报道了一锅法制造的油浸纳米胶囊，用RAFT制成的糖聚合物和中性多糖（葡聚糖和支链淀粉）包裹。我们利用了纳米沉淀技术，在根据相图的解释彻底确定的条件下，依靠油和聚合物的共沉淀。分别通过同时或顺序的纳米沉淀获得混合的单层或多层纳米胶囊。合成糖聚合物链的掺入允许精确地定制纳米胶囊的尺寸（聚合物壳的尺寸和膜厚度），而多糖的插入能够调节纳米胶囊的（生物）降解能力。壳功能化和/或核心加载的胶囊也可以通过类似的一锅法完成，

更新日期：2020-06-24

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