The influence of rs139416141 in neighbor of Brca1 gene (NBR1) on bone mineral density in postmenopausal Chinese women.,Acta Biochimica et Biophysica Sinica

当前位置： X-MOL 学术 › Acta Biochim. Biophys. Sin. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The influence of rs139416141 in neighbor of Brca1 gene (NBR1) on bone mineral density in postmenopausal Chinese women.
Acta Biochimica et Biophysica Sinica ( IF 3.3 ) Pub Date : 2020-06-23 , DOI: 10.1093/abbs/gmaa070
Yang Zhang ₁ , Zhenlin Zhang ₂ , Zinan Zhang ₃ , Lijie Zhao ₄ , Ying Xue ₁ , Haojie Wu ₁ , Jianming Hou _{1,

5}

Affiliation

Bone mineral density (BMD) is used to assess bone mass at present and ~70% of the variance is determined by genetic factors [1]. BMD in a lifetime is in a dynamic change from peak values obtained during growth to a gradual decrease during postmenopause and aging. Bone micro-architecture deterioration in postmenopausal women is a result of increased bone remodeling and liable to fracture of the hip, wrist and spine [2]. This bone remodeling imbalance due to estrogen deficiency causes skeletal tissues in the state of enhancement of osteoclastogenesis and impairment of osteogenesis.

更新日期：2020-06-23

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11