Noncovalent encapsulation of multiple guest molecules with distinct physiochemical properties, especially hydrophilic and hydrophobic guests, into a single polymeric nanoassembly is challenging, but would be profoundly beneficial to combine with therapeutic delivery strategies. Here, we report a nanocomposite coassembled by coating a layer of an amphiphilic block copolymer onto the surface of a cross-linked inverse micelle driven by hydrophobic interactions. The hydrophobic coating layer and water-filled inverse micelles were utilized to encapsulate hydrophobic and hydrophilic cargos, respectively. Rationally introducing the pH and redox responsive moieties into the coating polymer and inverse micelles allows to sequentially address the triggered release of the encapsulated cargos.

中文翻译：

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具有疏水性和亲水性的可顺序寻址主体-客体特性的三嵌段-二嵌段复合纳米组件

具有不同理化特性的多个客体分子（尤其是亲水性和疏水性客体）非共价封装到单个聚合物纳米组件中具有挑战性，但与治疗性递送策略相结合将具有极大的益处。在这里，我们报告了一种纳米复合材料，它通过在疏水相互作用驱动的交联反胶束表面上涂覆两亲嵌段共聚物层而共组装而成。疏水涂层和充水的反胶束分别用于包裹疏水和亲水货物。将pH和氧化还原响应部分合理地引入包衣聚合物和反胶束中，可以顺序解决封装货物的触发释放问题。