In this work, an innovative doxorubicin (DOX) imprinted photoluminescent polymer via the precipitation free-radical polymerization strategy was developed based on graphene quantum dots as a pH-responsive nanocarrier. The prepared materials were characterized by Fourier transform infrared, scanning electron microscopy, photoluminescence, and dynamic light scattering techniques. Binding kinetics of DOX established specific recognition binding sites in the photoluminescent nanoscale molecularly imprinted polymer (PLMIP) structure. In vitro drug release behaviors exhibited a pH-controlled release in a sustained manner for the prepared photoluminescent nanocarriers. Due to the presence of pseudopeptide skeletons in the nanocarrier and a positively charged structure, the cytotoxicity study indicated that a DOX-loaded nanocarrier against human lung adenocarcinoma A549 cell lines has notable cytotoxicity. According to the obtained results, the prepared pH-responsive PLMIP has the potential to be employed as an anticancer and biodetection platform.

中文翻译：

---

多柔比星印迹光致发光聚合物作为 pH 响应纳米载体

在这项工作中，基于石墨烯量子点作为 pH 响应纳米载体，通过沉淀自由基聚合策略开发了一种创新的多柔比星 (DOX) 印迹光致发光聚合物。所制备的材料通过傅里叶变换红外、扫描电子显微镜、光致发光和动态光散射技术进行了表征。DOX 的结合动力学在光致发光纳米级分子印迹聚合物 (PLMIP) 结构中建立了特异性识别结合位点。体外对于制备的光致发光纳米载体，药物释放行为表现出以持续方式受pH控制的释放。由于纳米载体中存在假肽骨架和带正电荷的结构，细胞毒性研究表明负载 DOX 的纳米载体对人肺腺癌细胞 A549 细胞系具有显着的细胞毒性。根据获得的结果，制备的 pH 响应 PLMIP 具有用作抗癌和生物检测平台的潜力。