Abstract

This meta-analysis aimed to investigate the association of the rs9939609 FTO gene polymorphism and body fat percentage (BF%). To the best of our knowledge, this study is the first meta-analysis to evaluate the relationship between FTO rs9939609 polymorphism and BF%. We searched PubMed, Web of science, Scopus and Embase to identify studies investigating the relations between the rs9939609 FTO gene polymorphism and BF%. Studies that meet inclusion criteria were collected for the final analysis. There was significant differences in the level of BF% between different genotypes of FTO rs9939609 polymorphism, and the carriers of the A allele of FTO rs9939609 polymorphism had higher BF%. The association was significant between carriers of TT genotype compared to carriers of AA (p = .007) and AT genotypes (p = .04), but not between AT and AA genotypes. This study identified that the carriers of the A allele of FTO rs9939609 polymorphism have higher BF%.

摘要

本荟萃分析旨在研究 rs9939609 FTO 基因多态性与体脂百分比 (BF%) 的关联。据我们所知，本研究是第一个评估 FTO rs9939609 多态性与 BF% 之间关系的荟萃分析。我们搜索了 PubMed、Web of science、Scopus 和 Embase，以确定调查 rs9939609 FTO 基因多态性与 BF% 之间关系的研究。收集符合纳入标准的研究用于最终分析。FTO rs9939609多态性不同基因型的BF%水平存在显着差异，FTO rs9939609多态性A等位基因携带者的BF%较高。与 AA ( p  = .007) 和 AT 基因型 (p  = .04)，但不在 AT 和 AA 基因型之间。本研究发现FTO rs9939609多态性A等位基因携带者的BF%较高。