Introduction

Proteomic research has been extensively used to identify potential biomarkers or targets for various diseases. Advances in mass spectrometry along with data analytics have led proteomics to become a powerful tool for exploring the critical molecular players associated with diseases, thereby, playing a significant role in the development of proteomic applications for the clinic.

Areas covered

This review presents recent advances in the development and clinical applications of proteomics in India toward understanding various diseases including cancer, metabolic diseases, and reproductive diseases. Keywords combined with ‘clinical proteomics in India’ ‘proteomic research in India’ and ‘mass spectrometry’ were used to search PubMed.

Expert opinion

The past decade has seen a significant increase in research in clinical proteomics in India. This approach has resulted in the development of proteomics-based marker technologies for disease management in the country. The majority of these investigations are still in the discovery phase and efforts have to be made to address the intended clinical use so that the identified potential biomarkers reach the clinic. To move toward this necessity, there is a pressing need to establish some key infrastructure requirements and meaningful collaborations between the clinicians and scientists which will enable more effective solutions to address health issues specific to India.

中文翻译：

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蛋白质组学的发展和临床应用：印度视角。

介绍

蛋白质组学研究已被广泛用于识别各种疾病的潜在生物标志物或靶标。质谱和数据分析的进步使蛋白质组学成为探索与疾病相关的关键分子参与者的强大工具，从而在临床蛋白质组学应用的发展中发挥重要作用。

覆盖区域

这篇综述介绍了印度蛋白质组学在了解包括癌症、代谢疾病和生殖疾病在内的各种疾病方面的发展和临床应用的最新进展。关键词结合“印度的临床蛋白质组学”“印度的蛋白质组学研究”和“质谱”被用于搜索PubMed。

专家意见

过去十年，印度临床蛋白质组学研究显着增加。这种方法导致该国开发了用于疾病管理的基于蛋白质组学的标记技术。大多数这些研究仍处于发现阶段，必须努力解决预期的临床用途，以便确定的潜在生物标志物进入临床。为了实现这一必要性，迫切需要建立一些关键的基础设施要求以及临床医生和科学家之间的有意义的合作，这将能够提供更有效的解决方案来解决印度特有的健康问题。