ABSTRACT

Given the devastating consequences of the current COVID-19 pandemic and its impact on all of us, the question arises as to whether manipulating the cellular degradation (recycling, waste disposal) mechanism known as macroautophagy/autophagy (in particular, the selective degradation of virus particles, termed virophagy) might be a beneficial approach to fight the novel coronavirus, SARS-CoV-2. Knowing that “autophagy can reprocess everything”, it seems almost inevitable that, sooner rather than later, a further hypothesis-driven work will detail the role of virophagy as a fundamental “disposal strategy” against COVID-19, yielding most needed therapeutic interventions.

Abbreviations: ATG, autophagy-related; CoV/CoVs coronavirus/coronaviruses; COVID-19, coronavirus disease 2019; MERS-CoV, Middle East respiratory syndrome coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2

摘要

鉴于当前的COVID-19大流行的灾难性后果及其对我们所有人的影响，出现了一个问题，即是否需要操纵称为自噬/自噬（特别是病毒的选择性降解）的细胞降解（回收，废物处理）机制颗粒，称为病毒吞噬）可能是对抗新型冠状病毒SARS-CoV-2的有益方法。知道“自噬可以重新处理所有东西”，几乎不可避免的是，不久以后，由假设驱动的工作将详细阐明自噬作为针对COVID-19的基本“处置策略”的作用，产生最需要的治疗干预措施。

缩写： ATG，与自噬有关；CoV / CoVs冠状病毒/冠状病毒；COVID-19，冠状病毒病2019; MERS-CoV，中东呼吸综合征冠状病毒；SARS-CoV-2，严重急性呼吸系统综合症冠状病毒2