Glutamate (Glu) is the most abundant excitatory neurotransmitter in the central nervous system (CNS). HIV-1 and viral proteins compromise glutamate synaptic transmission, resulting in poor cell-to-cell signaling and bystander toxicity. In this study, we identified that myeloid HIV-1-brain reservoirs survive in Glu and glutamine (Gln) as a major source of energy. Thus, we found a link between synaptic compromise, metabolomics of viral reservoirs, and viral persistence. In the current manuscript we will discuss all these interactions and the potential to achieve eradication and cure using this unique metabolic profile.

中文翻译：

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谷氨酸系统是中枢神经系统毒性和艾滋病毒储存生存的关键调节器。

谷氨酸（Glu）是中枢神经系统（CNS）中最丰富的兴奋性神经递质。HIV-1和病毒蛋白会破坏谷氨酸突触传递，导致差的细胞间信号传导和旁观者毒性。在这项研究中，我们确定了髓样HIV-1-脑储藏体在Glu和谷氨酰胺（Gln）中作为主要能量来源得以生存。因此，我们发现突触损害，病毒库的代谢组学和病毒持久性之间存在联系。在本手稿中，我们将讨论所有这些相互作用以及使用这种独特的代谢特征实现根除和治愈的潜力。