Abstract Hexanal is a 6-carbon aldehyde that smells like green leaves and urine to mammals. However, its physiological effects remain unclear. In particular, the effects of hexanal inhalation on the central nervous system have not been clarified. We investigated hexanal inhalation in mice and conducted a series of behavioral experiments to examine the neuropsychological effects of hexanal. After inhaling hexanal emissions for 30 min, mice were subjected to an open field test, a hot plate test, a grip strength test, an elevated plus maze test, a Y-maze test, a tail suspension test, and a forced swim test to examine the effects of hexanal odor on mouse behavior. Compared to controls, mice that inhaled hexanal exhibited reduced anxiety-like behavior in the elevated plus maze test. In addition, mice that inhaled hexanal displayed significantly improved spatial cognitive ability in the Y-maze test. However, in some behavioral experiments there was no significant difference between control mice and mice that inhaled hexanal. The results of this study suggest that hexanal inhalation causes anxiolytic effects and improves cognitive function in mice. These findings may have implications for safety management procedures and determining the effective use of household goods containing hexanal, though further work is required.

中文翻译：

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己醛吸入影响小鼠的认知和焦虑样行为

摘要 己醛是一种六碳醛，哺乳动物闻起来像绿叶和尿液。然而，其生理作用尚不清楚。特别是吸入己醛对中枢神经系统的影响尚未阐明。我们研究了小鼠的己醛吸入，并进行了一系列行为实验来检查己醛的神经心理学影响。吸入己醛排放物 30 min 后，对小鼠进行旷场试验、热板试验、握力试验、高架十字迷宫试验、Y 型迷宫试验、悬尾试验和强迫游泳试验。检查己醛气味对小鼠行为的影响。与对照组相比，吸入己醛的小鼠在高架十字迷宫测试中表现出减少的焦虑样行为。此外，吸入己醛的小鼠在 Y 迷宫测试中显示出显着提高的空间认知能力。然而，在一些行为实验中，对照小鼠和吸入己醛的小鼠之间没有显着差异。这项研究的结果表明，吸入己醛会引起抗焦虑作用并改善小鼠的认知功能。尽管需要进一步的工作，但这些发现可能对安全管理程序和确定有效使用含有己醛的家庭用品有影响。