There are growing interests in mechanical rupture-based antibacterial surfaces with nanostructures that have little toxicity to cells around the surfaces; however, current surfaces are fabricated via top-down nanotechnologies, which presents difficulties to apply for bio-surfaces with hierarchal three-dimensional structures. Herein, we developed ZnO/SiO₂ nanowire structures by using bottom-up approaches and demonstrated to show mechanical rupture-based antibacterial activity and compatibility with human cells. When Escherichia coli were cultured on the surface for 24 h, over 99% of the bacteria were inactivated, while more than 80% of HeLa cells that were cultured on the surface for 24 h were still alive. This is the first demonstration of mechanical rupture-based bacterial rupture via the hydrothermally synthesized nanowire structures with antibacterial activity and cell compatibility.

中文翻译：

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通过自下而上的方法形成基于机械断裂的抗菌和细胞兼容的 ZnO/SiO2 纳米线结构。


人们对基于机械破裂的纳米结构抗菌表面越来越感兴趣，这种纳米结构对表面周围的细胞几乎没有毒性；然而，当前的表面是通过自上而下的纳米技术制造的，这给应用于具有分层三维结构的生物表面带来了困难。在此，我们采用自下而上的方法开发了ZnO/SiO ₂纳米线结构，并证明其具有基于机械破裂的抗菌活性以及与人体细胞的相容性。当大肠杆菌在表面培养24小时时，99%以上的细菌被灭活，而在表面培养24小时80%以上的HeLa细胞仍然存活。这是通过具有抗菌活性和细胞相容性的水热合成纳米线结构首次演示基于机械破裂的细菌破裂。