Dedicated to Dr. Jacques Royer

Abstract

An improved synthesis of unsaturated γ-lactams by condensation of various primary amines with 2,5-dimethoxy-2,5-dihydrofuran is described. A modified mechanism for this reaction is suggested. Synthesis of their N-α-methoxylated derivatives, as N-acyliminium ion precursors, is also reported. Finally, a short synthesis of (±)-crispine A is presented as an illustrative application.

中文翻译：

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N-酰基亚胺离子化学：改善获得不饱和γ-内酰胺及其N-α-甲氧基化衍生物的途径：在（±）-Crispine A的快速合成中的应用

献给雅克·罗耶（Jacques Royer）博士

抽象

描述了通过各种伯胺与2，5-二甲氧基-2，5-二氢呋喃缩合的改进的不饱和γ-内酰胺的合成。建议对该反应进行改进的机理。还报道了它们的N -α-甲氧基化衍生物，作为N-酰基亚胺离子前体的合成。最后，提出了（±）-crispine A的简短合成作为说明性应用。