An iron-catalyzed direct O-alkylation of alcohols via α-C(sp3)–H activation of ethers and a thioether has been established that tolerates cyclic and acyclic ethers and alcohols containing aromatic N-heterocyclic moieties, providing an efficient and green method for the synthesis of mixed acetals with good to excellent yields. The robustness of this protocol is demonstrated by the late-stage oxidation of a structurally complex natural product.

中文翻译：

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用于合成混合缩醛的醚和硫醚与醇的铁催化直接交叉偶联

通过醚和硫醚的 α-C(sp3)-H 活化，铁催化的醇直接 O-烷基化已经建立，该硫醚耐受含有芳香族 N-杂环部分的环状和无环醚和醇，提供了一种有效和绿色的方法混合缩醛的合成具有良好的收率。该协议的稳健性由结构复杂的天然产物的后期氧化证明。