Synthesis of new‐type 1,3,6‐triazocine via intramolecular reactions of iodocyclization and [3+2] azido cycloaddition,Journal of Heterocyclic Chemistry

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Synthesis of new‐type 1,3,6‐triazocine via intramolecular reactions of iodocyclization and [3+2] azido cycloaddition
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-06-24 , DOI: 10.1002/jhet.4028
Ruslan I. Vaskevych _{1,

2} , Alla I. Vaskevych _{1,

3} , Eduard B. Rusanov ₁ , Oksana Ya. Mel'nyk ₄ , Mykhailo V. Vovk ₁

Affiliation

Selective iodocyclization of 6‐(alkenylamino)‐1‐allylpyrazolo[3,4‐d ]pyrimidines provided hydrogenated derivatives of 1‐allyl‐8(9)‐iodomethylimidazo(pyrimido)[1,2‐a ]pyrazolo[4,3‐e ]pyrimidines which were further reacted with NaN₃ at 75°С to 80°С to give a series of new‐type 1,3,6‐triazocines annulated with the pyrazole, pyrimidine, imidazole (or pyrimidine), and 1,2,3‐triazole rings. The compounds synthesized were structurally characterized by analytical, spectral (IR, ¹H and ¹³C NMR, HPLC‐mass), and X‐ray diffraction data.

中文翻译：

通过碘环化和[3 + 2]叠氮基环加成反应的分子内反应合成新型1,3,6-三唑嗪

6-（烯基氨基）-1-烯丙基吡唑并[ 3,4- d ]嘧啶的选择性碘环化提供了1-烯丙基-8（9）-碘甲基咪唑并（pyrimido）[1,2- a ]吡唑并[4,3- e ]嘧啶，在75°C至80°C下与NaN ₃进一步反应，得到一系列新型1,3,6-三唑嗪，与吡唑，嘧啶，咪唑（或嘧啶）和1,2 ，3-三唑环通过分析，光谱（IR，¹ H和¹³ C NMR，HPLC质量）和X射线衍射数据对合成的化合物进行结构表征。

更新日期：2020-08-08

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