Silyl protected nucleosides possess better biological activity. 2‐O‐silylated nucleosides were synthesized by trans opening of 1,2‐anhydrosugar with nucleobases where HMDS acts both as activating, and silylating agent. Conformational analysis and biofilm inhibition activity of synthesized nucleosides were performed.

中文翻译：

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来自未保护的核糖核酸和糖环氧化物的2 -O-甲硅烷基保护的核苷的合成和构象分析

甲硅烷基保护的核苷具有更好的生物活性。2- O-甲硅烷基化的核苷是通过将1,2-脱水糖与核苷反式合成的，其中HMDS既是活化剂，又是甲硅烷基化剂。进行了构象分析和生物膜抑制活性的合成核苷。