Time‐Economical Synthesis of Bis‐Spiro Cyclopropanes via Cascade 1,6‐Conjugate Addition/Dearomatization Reaction of para‐Quinone Methides with 3‐Chlorooxindoles,European Journal of Organic Chemistry

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Time‐Economical Synthesis of Bis‐Spiro Cyclopropanes via Cascade 1,6‐Conjugate Addition/Dearomatization Reaction of para‐Quinone Methides with 3‐Chlorooxindoles
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-06-24 , DOI: 10.1002/ejoc.202000830
Jing-Ru Zhang ₁ , Hai-Shan Jin ₁ , Jin Sun ₁ , Jie Wang ₁ , Li-Ming Zhao ₂

Affiliation

A simple method involving DBN‐mediated spirocyclopropanation of para‐quinone methides with 3‐chlorooxindoles is reported, providing a novel class of bis‐spiro compounds in short reaction times under mild conditions. Twenty‐four examples of the target compounds were obtained in up to 96 % yield.