Design and Characterization of a Novel Series of Geometrically Complex Intravaginal Rings with Digital Light Synthesis,Advanced Materials Technologies

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Design and Characterization of a Novel Series of Geometrically Complex Intravaginal Rings with Digital Light Synthesis
Advanced Materials Technologies ( IF 6.4 ) Pub Date : 2020-06-23 , DOI: 10.1002/admt.202000261
Rima Janusziewicz ₁ , Sue J Mecham ₂ , Kevin R Olson ₂ , S Rahima Benhabbour _{1,

3}

Affiliation

Intravaginal rings (IVRs) represent a sustained‐release approach to drug delivery and have long been used and investigated for hormones and microbicides delivery. For decades, IVRs have been manufactured by injection molding and hot‐melt extrusion with very limited design and material capabilities. Additive manufacturing (AM), specifically digital light synthesis (DLS), represents an opportunity to harness the freedom of design to expand control and tunability of drug release properties from IVRs. A novel approach to IVR design and manufacturing is reported that results in geometrically complex internal architectures through the incorporation of distinct unit cells using computationally aided design (CAD) software. A systematic approach is developed to design through the generation of an IVR library and the effects of these parameters are investigated on ring properties. The ability to precisely and predictably control the compressive properties of the IVR independent of the internal architecture with which control of drug release kinetics can be achieved is demonstrated, thus opening the door for a “plug‐and‐play” platform approach to IVR fabrication.

中文翻译：

具有数字光合成的新型几何复杂阴道环的设计和表征

阴道内环（IVR）代表了一种持续释放的药物递送方法，长期以来一直被用于激素和杀微生物剂的递送和研究。几十年来，IVR 一直通过注射成型和热熔挤出制造，设计和材料能力非常有限。增材制造 (AM)，特别是数字光合成 (DLS)，代表了利用设计自由扩展 IVR 药物释放特性的控制和可调性的机会。据报道，一种新的 IVR 设计和制造方法通过使用计算辅助设计 (CAD) 软件合并不同的单元来产生几何复杂的内部架构。通过生成 IVR 库开发了一种系统方法来进行设计，并研究了这些参数对环属性的影响。证明了独立于可以实现药物释放动力学控制的内部结构精确和可预测地控制 IVR 压缩特性的能力，从而为 IVR 制造的“即插即用”平台方法打开了大门。

更新日期：2020-08-10

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