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Autonomic and cardiovascular consequences resulting from experimental hemorrhagic stroke in the left or right intermediate insular cortex in rats
Autonomic Neuroscience ( IF 3.2 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.autneu.2020.102695 Fernanda Ribeiro Marins 1 , Marcelo Limborço-Filho 1 , Bárbara Flecha D'Abreu 1 , Pedro W Machado de Almeida 1 , Mariana Gavioli 1 , Carlos Henrique Xavier 2 , Stephen M Oppenheimer 3 , Silvia Guatimosim 1 , Marco Antônio Peliky Fontes 1
Autonomic Neuroscience ( IF 3.2 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.autneu.2020.102695 Fernanda Ribeiro Marins 1 , Marcelo Limborço-Filho 1 , Bárbara Flecha D'Abreu 1 , Pedro W Machado de Almeida 1 , Mariana Gavioli 1 , Carlos Henrique Xavier 2 , Stephen M Oppenheimer 3 , Silvia Guatimosim 1 , Marco Antônio Peliky Fontes 1
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Damage to the insular cortex (IC) results in serious cardiovascular consequences and evidence indicates that the characteristics are lateralized. However, a study comparing the effects of focal experimental hemorrhage between IC sides was never performed. We compared the cardiovascular, autonomic and cardiac changes produced by focal experimental hemorrhage (ICH) into the left (L) or right (R) IC. Wistar rats were submitted to microinjection of autologous blood (ICH) or saline (n = 6 each side/group) into the R or L IC. Blood pressure (BP), heart rate (HR) and renal sympathetic activity (RSNA) were recorded. Measurements of calcium transient and sarcoplasmic Ca2+ ATPase expression in cardiomyocytes were performed. ICH increased baseline HR (Δ:L-ICH 452 ± 13 vs saline 407 ± 11 bpm; R-ICH 450 ± 7 vs saline 406 ± 8 bpm, P < 0.05) without changing BP. HR was restored to baseline levels after i.v. atenolol. Strikingly, ICH rats presented a reduced baseline RSNA (Δ:L-ICH 122 ± 4 vs saline 148 ± 11 spikes/s; R-ICH 112 ± 5 vs saline 148 ± 7 spikes/s, P < 0.05). After 24 h of ICH we observed a marked increase in cardiac ectopies and this number was greater after ICH R-IC. Heart weight, calcium amplitude and SERCA expression were reduced only in ICH R-IC. Focal stroke into IC can alter the cardiac and renal autonomic control. Damage to the R-IC produces a greater number of arrhythmias and changes in calcium dynamics in cardiac cells indicating that the cardiovascular consequences are hemisphere-dependent. These findings confirm asymmetry for cardiac autonomic control at the IC and help to understand the cardiac and renal implications observed after specific side cortical damage.
中文翻译：
大鼠左侧或右侧中间岛叶皮层的实验性出血性中风导致的自主神经和心血管后果
对岛叶皮层 (IC) 的损伤会导致严重的心血管后果，并且有证据表明这些特征是偏侧化的。然而，从未进行过比较 IC 侧局部实验性出血影响的研究。我们将局灶性实验性出血 (ICH) 产生的心血管、自主神经和心脏变化与左侧 (L) 或右侧 (R) IC 进行了比较。将 Wistar 大鼠显微注射自体血液 (ICH) 或生理盐水（每侧/组 n = 6）到 R 或 L IC。记录血压 (BP)、心率 (HR) 和肾交感神经活动 (RSNA)。进行了心肌细胞中钙瞬变和肌浆 Ca2+ ATPase 表达的测量。ICH 增加基线 HR（Δ：L-ICH 452 ± 13 对生理盐水 407 ± 11 bpm；R-ICH 450 ± 7 对生理盐水 406 ± 8 bpm，P < 0。05）不改变BP。静脉注射阿替洛尔后，HR 恢复到基线水平。引人注目的是，ICH 大鼠呈现出降低的基线 RSNA（Δ：L-ICH 122 ± 4 对生理盐水 148 ± 11 峰值/秒；R-ICH 112 ± 5 对生理盐水 148 ± 7 峰值/秒，P < 0.05）。在 ICH 24 小时后，我们观察到心脏异位显着增加，并且在 ICH R-IC 后这个数字更大。心脏重量、钙振幅和 SERCA 表达仅在 ICH R-IC 中降低。局灶性卒中进入 IC 可以改变心脏和肾脏的自主神经控制。R-IC 的损伤会产生更多的心律失常和心肌细胞钙动力学的变化，表明心血管后果是半球依赖性的。
更新日期：2020-09-01
中文翻译：
大鼠左侧或右侧中间岛叶皮层的实验性出血性中风导致的自主神经和心血管后果
对岛叶皮层 (IC) 的损伤会导致严重的心血管后果，并且有证据表明这些特征是偏侧化的。然而，从未进行过比较 IC 侧局部实验性出血影响的研究。我们将局灶性实验性出血 (ICH) 产生的心血管、自主神经和心脏变化与左侧 (L) 或右侧 (R) IC 进行了比较。将 Wistar 大鼠显微注射自体血液 (ICH) 或生理盐水（每侧/组 n = 6）到 R 或 L IC。记录血压 (BP)、心率 (HR) 和肾交感神经活动 (RSNA)。进行了心肌细胞中钙瞬变和肌浆 Ca2+ ATPase 表达的测量。ICH 增加基线 HR（Δ：L-ICH 452 ± 13 对生理盐水 407 ± 11 bpm；R-ICH 450 ± 7 对生理盐水 406 ± 8 bpm，P < 0。05）不改变BP。静脉注射阿替洛尔后，HR 恢复到基线水平。引人注目的是，ICH 大鼠呈现出降低的基线 RSNA（Δ：L-ICH 122 ± 4 对生理盐水 148 ± 11 峰值/秒；R-ICH 112 ± 5 对生理盐水 148 ± 7 峰值/秒，P < 0.05）。在 ICH 24 小时后，我们观察到心脏异位显着增加，并且在 ICH R-IC 后这个数字更大。心脏重量、钙振幅和 SERCA 表达仅在 ICH R-IC 中降低。局灶性卒中进入 IC 可以改变心脏和肾脏的自主神经控制。R-IC 的损伤会产生更多的心律失常和心肌细胞钙动力学的变化，表明心血管后果是半球依赖性的。
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