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The memory of the fatty acid system.
Progress in Lipid Research ( IF 14.0 ) Pub Date : 2020-06-24 , DOI: 10.1016/j.plipres.2020.101049
Rainer H Straub 1
Affiliation  

Mental memory system has sensory memory, short-term memory, working memory, and long-term memory. Working memory “keeps things in mind in parallel” when performing complex tasks. Similar aspects can be found for immunological memory. However, there exists another one, the memory of the fatty acid system.

This article shows sensory memory of the fatty acid system, which is the perception apparatus of small intestine enterocytes (CD36, SR-B1, FATP4, FABP1, FABP2) and hepatocytes. In these cells, the fatty acid short-term memory is located, consisting of a cytoplasmic lipid droplet cycle. Similar like a working memory in the brain, the short-term memory of enterocytes and hepatocytes use parallel processing and recourse to long-term fatty acid memory. The fatty acid long-term memory is far away from these primary points of uptake. It is located in the adipocyte and in cellular membranes.

The process of building a fatty acid memory is described with constructs like sensing environmental material, encoding, consolidation, long-term storage, retrieval, re-encoding, re-consolidation, and renewed long-term storage.

The article illustrates the dynamics of building a fatty acid memory, the information content of fatty acids including the code, the roles of fatty acids in the body, and a new understanding of the expression “you are what you eat”. The memory of the fatty acid system, plays a decisive role in integrating environmental signals over time (diet and microbiome).



中文翻译:

脂肪酸系统的记忆。

精神记忆系统具有感觉记忆,短期记忆,工作记忆和长期记忆。当执行复杂的任务时,工作记忆“并行地记住事情”。可以发现免疫记忆的相似方面。然而,存在另一种,脂肪酸系统的记忆。

本文显示了脂肪酸系统的感觉记忆,该系统是小肠肠上皮细胞(CD36,SR-B1,FATP4,FABP1,FABP2)和肝细胞的感知器。在这些细胞中,定位了脂肪酸的短期记忆,由细胞质脂质小滴循环组成。类似于大脑中的工作记忆,肠细胞和肝细胞的短期记忆使用并行处理并求助于长期脂肪酸记忆。脂肪酸的长期记忆距离这些摄取的主要点很远。它位于脂肪细胞和细胞膜中。

用诸如感测环境材料,编码,合并,长期存储,检索,重新编码,重新合并和更新的长期存储之类的构造来描述建立脂肪酸存储器的过程。

这篇文章说明了建立脂肪酸记忆的动力学,脂肪酸的信息内容(包括代码),脂肪酸在体内的作用以及对“您就是所吃的东西”这一表达的新理解。脂肪酸系统的记忆在整合环境信号(饮食和微生物组)中起着决定性的作用。

更新日期:2020-06-24
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