This review focuses on albumin, which is involved in multidirectional interactions among the immune, endocrine and serotoninergic systems and supervises the regulation of cytochrome P450 (CYP) isoforms under conditions of both normal liver function and liver insufficiency. Special attention is paid to albumin, thyroid hormones, testosterone and tryptophan hydroxylase in these interactions as well as their potential roles in liver regeneration. The association of these factors with inflammation and the modification of the mechanism of hepatic drug-metabolizing CYP isoform regulation are also presented because changes in the expression of CYP isoforms in the liver may result in subsequent changes to a marker substance used for testing CYP activity, thus providing a simple way to control the liver regeneration process or the dangerous stimulation of hepatocarcinogenesis.

本综述重点关注白蛋白，白蛋白参与免疫、内分泌和 5-羟色胺能系统之间的多向相互作用，并在正常肝功能和肝功能不全的情况下监督细胞色素 P450 (CYP) 亚型的调节。特别注意白蛋白、甲状腺激素、睾酮和色氨酸羟化酶在这些相互作用中以及它们在肝脏再生中的潜在作用。这些因素与炎症的关联以及肝脏药物代谢 CYP 同种型调节机制的改变也被提出，因为肝脏中 CYP 同种型表达的变化可能导致随后用于测试 CYP 活性的标记物质发生变化，