The coronavirus disease 2019 (COVID-19) is a new type of pneumonia caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. COVID-19 is affecting millions of patients, and the infected number keeps increasing. SARS-CoV-2 is highly infectious, has a long incubation period, and causes a relatively high death rate, resulting in severe health problems all over the world. Currently there is no effective proven drug for the treatment of COVID-19; therefore, development of effective therapeutic drugs to suppress SARS-CoV-2 infection is urgently needed. In this review, we first summarize the structure and genome features of SARS-CoV-2 and introduce its infection and replication process. Then, we review the clinical symptoms, diagnosis, and treatment options of COVID-19 patients. We further discuss the potential molecular targets and drug development strategies for treatment of the emerging COVID-19. Finally, we summarize clinical trials of some potential therapeutic drugs and the results of vaccine development. This review provides some insights for the treatment of COVID-19.

2019年冠状病毒病（COVID-19）是由严重急性呼吸综合征冠状病毒-2（SARS-CoV-2）感染引起的新型肺炎。COVID-19 正在影响数百万患者，并且感染人数不断增加。SARS-CoV-2传染性强、潜伏期长、死亡率较高，给全世界带来了严重的健康问题。目前尚无有效的已证实药物可用于治疗 COVID-19；因此，迫切需要开发有效的治疗药物来抑制SARS-CoV-2感染。在这篇综述中，我们首先总结了SARS-CoV-2的结构和基因组特征，并介绍了其感染和复制过程。然后，我们回顾了 COVID-19 患者的临床症状、诊断和治疗方案。我们进一步讨论治疗新出现的 COVID-19 的潜在分子靶点和药物开发策略。最后，我们总结了一些潜在治疗药物的临床试验和疫苗开发的结果。这篇综述为 COVID-19 的治疗提供了一些见解。