Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust.

抗体依赖性增强（ADE）是通常与登革热病毒再感染相关的非典型免疫悖论。但是，各种研究模型已与包括Coronaviridae在内的其他病毒家族一起证明了这一现象。最近，SARS-CoV-2中的ADE成为解释严重临床表现的一种假设。ADE是否能增强SARS-CoV-2尚无定论，因此引起了人们对该现象归因于大流行的批评。因此，在SARS-CoV-2疫苗开发中对ADE进行严格的评估将是必不可少的，以避免全球性的挫折和公众信任的侵蚀。