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Propargyl alcohols as alkyne sources: Synthesis of heterocyclic compounds under microwave irradiation
Journal of Organometallic Chemistry ( IF 2.1 ) Pub Date : 2020-06-24 , DOI: 10.1016/j.jorganchem.2020.121350
Karu Ramesh , Gedu Satyanarayana

Fused heterocyclic compounds with alkyne substituent, have been achieved using a domino microwave-assisted [Pd]-catalysis. Interestingly, tert-propargyl alcohols underwent a selective degradative β-carbon cleavage and served as masked alkynyl equivalents, in water as the sole reaction medium. Dihydrobenzofurans, indolines, and oxindoles have been accomplished using this dual C–C bond-forming strategy.



中文翻译:

炔丙醇作为炔烃源:微波辐射下杂环化合物的合成

使用多米诺骨牌微波辅助[Pd]催化已经实现了具有炔烃取代基的稠合杂环化合物。有趣的是,炔丙基醇在水中作为唯一的反应介质,经历了选择性的降解β-碳裂解,并作为掩蔽的炔基当量。使用这种双重CC键形成策略已经完成了二氢苯并呋喃,二氢吲哚和羟吲哚。

更新日期:2020-07-07
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