Exercise has been shown to increase myelin biomarkers such as klotho and PLP and improve clinical and pathological symptoms using the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). In the present study, we evaluated whether 6 weeks of high-intensity interval training (HIIT) prior to induction of EAE increase klotho and/or PLP and attenuate the severity of symptoms and/or disease progression in EAE model. Our data demonstrate that HIIT increased klotho and PLP and decreased disability. These proteins are associated with maintaining myelination and further research is required to examine potential clinical relevance.

中文翻译：

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6周高强度间歇训练对实验性自身免疫性脑脊髓炎模型髓鞘生物标志物和脱髓鞘的影响

使用多发性硬化症 (MS) 的实验性自身免疫性脑脊髓炎 (EAE) 模型，运动已被证明可以增加髓鞘生物标志物，如 klotho 和 PLP，并改善临床和病理症状。在本研究中，我们评估了 EAE 诱导前 6 周的高强度间歇训练 (HIIT) 是否会增加 klotho 和/或 PLP，并减轻 EAE 模型中症状和/或疾病进展的严重程度。我们的数据表明 HIIT 增加了 klotho 和 PLP 并减少了残疾。这些蛋白质与维持髓鞘形成有关，需要进一步研究以检查潜在的临床相关性。