This work deals with the kinetic modeling of the synthesis of isobutyl acetate by liquid-phase esterification of isobutanol with acetic acid, in presence of the heterogeneous catalyst Amberlyst 15. Based upon a statistical experimental design, isothermal batch experiments were performed in the temperature range of 343.15–373.15 K, at three different catalyst loadings, and at different acid to alcohol mole ratios (1:1, 2:1 and 1:2). Preliminary experiments were run to assess the effects of internal and external mass transfer phenomena, and they were ruled out based upon the Weisz–Prater criterion. Thus, further experiments were run at stirring rates of 800 RPM, and catalyst particle diameters under 300 μm to ensure a kinetic regime. Independent experiments were run to obtain the chemical equilibrium constant at different temperatures, and by mean of a van’t Hoff equation, a ΔH_R of 16.47 kJ/mol was obtained. Incorporating the equilibrium constant, the kinetic experimental data were regressed with a molar fraction-based pseudo homogeneous model. The obtained model accurately fits experiments and it can be used for further simulation of reactive distillation processes for isobutyl acetate production.

这项工作涉及在异相催化剂Amberlyst 15存在下通过异丁醇与乙酸的液相酯化反应合成乙酸异丁酯的动力学模型。基于统计实验设计，在25℃的温度范围内进行了等温分批实验。 343.15–373.15 K，三种不同的催化剂负载量，以及不同的酸与醇摩尔比（1：1、2：1和1：2）。进行了初步实验以评估内部和外部传质现象的影响，并且根据Weisz–Prater标准将其排除在外。因此，进一步的实验以800 RPM的搅拌速度进行，催化剂颗粒直径小于300μm，以确保动力学。进行独立实验以获取不同温度下的化学平衡常数，获得16.47kJ / mol的_R。结合平衡常数，将动力学实验数据与基于摩尔分数的伪均质模型进行回归。所获得的模型准确地适合于实验，并且可以用于进一步模拟乙酸异丁酯生产的反应蒸馏过程。