Abstract Salacia chinensis (SC) is generally known as Saptrangi, which has been used as an herb in Ayurvedic medicine and has a broad range of biological applications. The current research was planned to develop Salacia chinensis-loaded gold nanoparticles (SC-AuNPs) and to assess the anti-obesity parameters in a high-fat diet (HFD) treated obese rats. SC-AuNPs were synthesized and characterized using UV-visible spectroscopy, SEM, FTIR, EDX, XRD, and TEM. Furthermore, the bodyweight changes, BMI, adipose index, leptin, resistin, adiponectin, AI, CRI, liver marker enzymes, inflammatory markers, lipid profile, AMPK signaling proteins, and liver histopathological changes were analyzed. We observed that the synthesized SC-AuNPs had a spherical shape, crystalline nature, and possessed a different functional group. The SC-AuNPs treatments also decreased body weight, BMI, adipose index, leptin, resistin, AI, CRI, liver marker enzymes, lipid profile, inflammatory markers, and AMPKα1. On the other hand, SC-AuNPs treatment increased adiponectin, HDL-C, and pAMPKα1. The histopathological findings showed improved result with reduced hepatocyte degradation under the influence of SC-AuNPs treatment.

中文翻译：

---

五层龙合成金纳米粒子的抗肥胖活性通过AMPK信号通路调节高脂饮食诱导肥胖大鼠模型的生化变化

摘要 五层龙(Salacia chinensis, SC) 通常被称为Saptrangi，它已被用作阿育吠陀医学中的草本植物，并具有广泛的生物学应用。目前的研究计划开发载有五层龙的金纳米粒子 (SC-AuNPs) 并评估高脂饮食 (HFD) 治疗的肥胖大鼠的抗肥胖参数。SC-AuNPs 使用紫外-可见光谱、SEM、FTIR、EDX、XRD 和 TEM 合成和表征。此外，还分析了体重变化、BMI、脂肪指数、瘦素、抵抗素、脂联素、AI、CRI、肝脏标志酶、炎症标志物、脂质谱、AMPK信号蛋白和肝脏组织病理学变化。我们观察到合成的 SC-AuNPs 具有球形、结晶性质，并具有不同的官能团。SC-AuNPs 治疗还降低了体重、BMI、脂肪指数、瘦素、抵抗素、AI、CRI、肝脏标记酶、脂质谱、炎症标记和 AMPKα1。另一方面，SC-AuNPs 处理增加了脂联素、HDL-C 和 pAMPKα1。组织病理学结果显示，在 SC-AuNPs 处理的影响下，肝细胞降解减少，结果得到改善。