Abstract Capecitabine, known as an anti-cancer drug, despite clinical evidence in the general society of patients, the absence of specific data from the perception of increased toxic effects in older people and randomized trials, can be harmful to the body. So, its measurement is essential. A novel electrochemical sensor was fabricated based on glassy carbon electrode (GCE) decorated by molecularly imprinted polymer (MIP)-coated magnetic nanocomposite of iron (II, III) oxide @graphene oxide (Fe3O4@GO) for the detection of capecitabine. The MIP was deposited on the surface of core@shell nanocomposite by non-covalent imprinting process. Fe3O4@GO@MIP composite was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR) techniques. The electrochemical performance of proposed sensor was investigated by cyclic and square wave voltammetry techniques. Several parameters such as the electrochemical behavior of the modified electrodes, the type and pH value of supporting electrolyte and scan rates were studied. Under the optimized conditions, the linear range and detection limit were obtained 1.0–100.0 nM and 0.324 nM, respectively. The proposed electrode was successfully applied to the quantification of capecitabine in health human plasma and pharmaceutical samples.

中文翻译：

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基于磁性核@壳分子印迹纳米复合材料（Fe3O4@Graphene Oxide@MIP）的新型电化学传感器用于灵敏和选择性测定抗癌药物卡培他滨

摘要 卡培他滨被称为抗癌药物，尽管在一般患者社会中获得了临床证据，但缺乏对老年人毒性作用增加的感知和随机试验的具体数据，可能对身体有害。因此，它的测量是必不可少的。基于由分子印迹聚合物（MIP）涂覆的铁（II，III）氧化物@氧化石墨烯（Fe3O4@GO）磁性纳米复合材料装饰的玻碳电极（GCE）制造了一种新型电化学传感器，用于检测卡培他滨。MIP通过非共价压印工艺沉积在核@壳纳米复合材料的表面。Fe3O4@GO@MIP 复合材料通过透射电子显微镜 (TEM)、扫描电子显微镜 (SEM)、X 射线衍射 (XRD) 和傅里叶变换红外光谱 (FT-IR) 技术进行表征。通过循环和方波伏安法技术研究了所提出的传感器的电化学性能。研究了修饰电极的电化学行为、支持电解质的类型和pH值以及扫描速率等几个参数。在优化条件下，线性范围和检测限分别为 1.0–100.0 nM 和 0.324 nM。所提出的电极已成功应用于健康人体血浆和药物样品中卡培他滨的定量。线性范围和检测限分别为 1.0–100.0 nM 和 0.324 nM。所提出的电极已成功应用于健康人体血浆和药物样品中卡培他滨的定量。线性范围和检测限分别为 1.0–100.0 nM 和 0.324 nM。所提出的电极已成功应用于健康人体血浆和药物样品中卡培他滨的定量。