Genetic polymorphisms of genes whose products are responsible for activities, such as xenobiotic metabolism, mutagen detoxification and DNA-repair, have been predicted to be associated with the risk of developing lung cancer (LC). The association of LC with tobacco smoking has been extensively investigated, but no studies have focused on the Arab ethnicity. Previously, we examined the association between genetic polymorphisms among Phase I and Phase II metabolism genes and the risk of LC. Here, we extend the data by examining the correlation of OGG1 Ser326Cys combined with CYP1A1 (Ile462Val and MspI) and GSTP1 (Ile105Val and Ala103Val) polymorphisms with the risk of LC. Polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) and gene sequencing were carried out for genotyping the OGG1 polymorphisms of 123 LC patients and 129 controls. No significant differences in the frequencies of the OGG1 mutant allele between patients and controls were found. The distributions of heterozygous Ser/Cys or Cys/Cys genotypes of OGG1 were not associated with the risk of LC either according to the histological types of LC or based on waterpipe tobacco (WP) smoking status. In contrast, the combined effect of OGG1 variants with CYP1A1 and GSTP1 variants revealed a significant correlation with the OGG1 Ser326Cys—CYP1A1 MspI variants pairing. This association was significant (p = 0.001) in individuals who carried homozygous or heterozygous variant type genotypes of both genes in a reference with carriers of both wild-type genotypes (wt/wt − wt/wt). The odds ratios were 2.99 (95% CI 1.67–5.36), 2.68 (95% CI 1.08–6.62), and 2.80 (95% CI 1.18–6.69) for those who carried (wt/wt − wt/vt + vt/vt), (wt/vt + vt/vt − wt/wt), and (wt/vt + vt/vt − wt/vt + vt/vt), respectively. The study suggests a limited correlation is present between carrying OGG1 Ser326Cys polymorphism and the risk of developing LC in Arab populations.

据预测，其产物负责活动的基因的遗传多态性，如异种生物代谢，诱变剂解毒和DNA修复，与患肺癌（LC）的风险有关。LC与吸烟之间的关联已得到广泛研究，但还没有针对阿拉伯种族的研究。以前，我们检查了I期和II期代谢基因之间的遗传多态性与LC风险之间的关联。在这里，我们通过检查OGG1 Ser326Cys与CYP1A1（Ile462Val和MspI）和GSTP1的相关性来扩展数据（Ile105Val和Ala103Val）多态性具有LC风险。对123例LC患者和129例对照的OGG1基因多态性进行了聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和基因测序。在患者和对照之间未发现OGG1突变等位基因频率的显着差异。根据LC的组织学类型或基于水烟的吸烟状态，OGG1杂合的Ser / Cys或Cys / Cys基因型的分布与LC的风险无关。相反，OGG1变体与CYP1A1和GSTP1的组合作用变种透露与一个显著相关OGG1 Ser326Cys- CYP1A1 MspI的变种配对。 在携带两种基因的纯合子或杂合子变异型基因型的个体中，两种野生型基因型（wt / wt-wt / wt）的携带者之间的这种关联是显着的（p = 0.001）。携带者（wt / wt-wt / vt + vt / vt）的优势比为2.99（95％CI 1.67–5.36），2.68（95％CI 1.08–6.62）和2.80（95％CI 1.18–6.69） ），（wt / vt + vt / vt-wt / wt）和（wt / vt + vt / vt-wt / vt + vt / vt）。研究表明，携带OGG1 Ser326Cys多态性与阿拉伯人群发生LC的风险之间存在有限的相关性。