Recently, natural antioxidant substances have been purified in a significant increasing incline from different plants for diagnosis and treatment options. In the current study, Resveratrol (RES) was isolated and radioiodinated with iodine-131 ([ 131 I]iodo-RES). Cell culture studies were conducted on neuroblastoma cells (SY-SH5Y and SK-N-AS) to investigate the bioavailability of [ 131 I]iodo-RES. The radioiodination yield of RES was 98.81 ± 0.37% (n = 6). Uptake values up to 25% were observed notably on SK-N-AS cells until 24 h. Briefly; the current study will contribute to the development of novel radiolabeled plant origin agents for the imaging of neuroblastoma cells.

中文翻译：

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从花生芽中分离白藜芦醇、放射性碘及其对神经母细胞瘤细胞系的生物活性研究

最近，从不同植物中提纯天然抗氧化物质的趋势显着增加，用于诊断和治疗选择。在当前的研究中，白藜芦醇 (RES) 被分离出来并用碘 131 ([ 131 I]iodo-RES) 进行放射性碘化。对神经母细胞瘤细胞（SY-SH5Y 和 SK-N-AS）进行了细胞培养研究，以研究 [ 131 I] 碘-RES 的生物利用度。RES 的放射性碘化率为 98.81 ± 0.37% (n = 6)。在 SK-N-AS 细胞上观察到高达 25% 的摄取值，直到 24 小时。简要地; 目前的研究将有助于开发用于神经母细胞瘤细胞成像的新型放射性标记植物来源试剂。