COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction and aberrant coagulation in small and large vessels. This review addresses some of the pathways leading to endothelial derangement, such as complement, HIF-1α, and ABL tyrosine kinases. This review also highlights potential targets for prevention and therapy of COVID-19-related organ damage and discusses the role of marketed drugs, such as eculizumab and imatinib, as suitable candidates for clinical trials.

中文翻译：

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COVID-19驱动的内皮损伤：补体，HIF-1和ABL2是潜在的损伤途径和治疗靶标。

COVID-19大流行病是一种重大的卫生突发事件，在世界范围内造成数百人死亡。报道的高发病率与低氧和炎症有关，导致小血管和大血管的内皮功能障碍和凝血异常。这项审查解决了一些导致内皮功能紊乱的途径，例如补体，HIF-1α和ABL酪氨酸激酶。这篇综述还着重介绍了预防和治疗COVID-19相关器官损伤的潜在目标，并讨论了市售药物如依库丽单抗和伊马替尼的临床试验作用。