Oxidative stress (OS) is a key contributing factor in 30–80% of male infertility cases. To date, several antioxidant treatments have been put forth to manage OS-induced male infertility. This study intended to elucidate the impact of coenzyme Q10 (CoQ10) and selenium on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia (OAT). In this prospective study, 70 patients with idiopathic OAT were randomly allocated to receive CoQ10 (200 mg/day) or selenium (200 μg/day) for 3 months. Semen quality parameters (following WHO guidelines, 5th edition), total antioxidant capacity (TAC), catalase (CAT), and superoxide dismutase (SOD) activities were compared before and after the treatment. The results of the study showed an increase in sperm concentration with CoQ10 treatment (p < 0.01) as well as increased progressive sperm motility (p < 0.01 and p < 0.05) and total sperm motility (p < 0.01 and p < 0.05) with CoQ10 and selenium treatment respectively. There was also a significant improvement in TAC (p < 0.01 and p < 0.05) and SOD (p < 0.01 and p < 0.05) following treatment with CoQ10 and selenium respectively while CAT improved only with CoQ10 therapy (p < 0.05). Sperm concentration, motility, and morphology also correlated significantly with TAC, SOD, and CAT (r = 0.37–0.76). In conclusion, treatment with CoQ10 (200 mg) or selenium (200 μg) could improve sperm concentration, motility, and antioxidant status in infertile men with idiopathic OAT with CoQ10 providing the higher improvement.

氧化应激（OS）是30-80％男性不育病例的关键因素。迄今为止，已经提出了几种抗氧化剂治疗来控制OS引起的男性不育。这项研究旨在阐明辅酶Q10（CoQ10）和硒对患有特发性少儿无精症（OAT）的不育男性精液参数和抗氧化状态的影响。在这项前瞻性研究中，将70名特发性OAT患者随机分配接受CoQ10（200 mg /天）或硒（200μg/天）治疗3个月。比较治疗前后的精液质量参数（遵循WHO指南，第5版），总抗氧化能力（TAC），过氧化氢酶（CAT）和超氧化物歧化酶（SOD）活性。研究结果显示辅酶Q10处理可使精子浓度增加（p 分别用CoQ10和硒处理后， 精子活力<0.01）以及进行性精子活动性提高（p  <0.01和p  <0.05）和总精子运动性（p  <0.01和p <0.05）。 分别用CoQ10和硒治疗后，TAC（p  <0.01和p  <0.05）和SOD（p  <0.01和p <0.05）也有显着改善，而CAT仅通过CoQ10治疗得到改善（p  <0.05）。精子浓度，运动性和形态也与TAC，SOD和CAT显着相关（r = 0.37–0.76）。总而言之，用CoQ10（200 mg）或硒（200μg）治疗可以改善患有特发性OAT的不育男性中CoQ10的精子浓度，运动性和抗氧化剂状态，从而提供更高的改善。