A simple and cost-effective route to fabricating the gold-coated glass nano-stings' arrays is presented for highly efficient surface enhanced Raman spectroscopy (SERS) chips via reactive ion etching of the glass slide covered with polystyrene (PS) colloidal monolayer and sputtering deposition of gold on it. The as-fabricated SERS chips consist of the nearly-hemispherical particles with submicron-size, which are hexagonally arranged into the ordered arrays. There are many short and long Au-coated glass nano-stings standing vertically on the hemispherical particles, showing high density tips (up to 7.0  103/m2). The formation of such gold-coated glass hierarchically structured array is attributed to the geometry of PS colloidal monolayer and the nanoscale roughness of glass slide's surface. Further, it has been demonstrated that such gold-coated glass array chip is highly SERS-active and can be utilized to detect trace organophosphorous toxicant with the limit below ppt level and good reproducibility in measurements. The intensity of the Raman peak shows the linear relation, in logarithmic scale, with the organophosphorous concentration from ppt to ppm level, exhibiting the possibility of quantitative detection in a large concentration range. This work has demonstrated the cost-effective method to fabricate the high performance SERS chips for trace detection of toxic molecules.

中文翻译：

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具有大密度尖端的有序镀金玻璃纳米刺阵列作为高 SERS 活性芯片，用于检测痕量有机磷毒物

通过对覆盖有聚苯乙烯 (PS) 胶体单层的载玻片进行反应离子蚀刻和溅射，为高效表面增强拉曼光谱 (SERS) 芯片提供了一种简单且经济高效的制造镀金玻璃纳米刺阵列的方法在其上沉积黄金。制造的 SERS 芯片由亚微米级的近半球形颗粒组成，这些颗粒呈六边形排列成有序阵列。半球形颗粒上有许多短而长的镀金玻璃纳米针垂直竖立，呈现出高密度的尖端（高达7.0×103/m2）。这种镀金玻璃分层结构阵列的形成归因于 PS 胶体单层的几何形状和载玻片表面的纳米级粗糙度。更多，已经证明，这种镀金玻璃阵列芯片具有高度的 SERS 活性，可用于检测痕量有机磷毒物，其限值低于 ppt 水平，且测量重现性良好。拉曼峰强度与有机磷浓度从 ppt 到 ppm 级呈对数线性关系，显示出在大浓度范围内进行定量检测的可能性。这项工作证明了制造用于有毒分子痕量检测的高性能 SERS 芯片的成本效益高的方法。有机磷浓度从 ppt 到 ppm 级，显示出在大浓度范围内进行定量检测的可能性。这项工作证明了制造用于有毒分子痕量检测的高性能 SERS 芯片的成本效益高的方法。有机磷浓度从 ppt 到 ppm 级，显示出在大浓度范围内进行定量检测的可能性。这项工作证明了制造用于有毒分子痕量检测的高性能 SERS 芯片的成本效益高的方法。