Limited mitochondria outer membrane permeability (MOMP) is a novel biological process where mammalian cells initiate the intrinsic apoptosis pathway with increased mitochondrial permeability but survive. One of the major consequences of limited MOMP is apoptotic endonuclease-induced DNA double strand breaks. Recent studies indicate that these DNA double stand breaks and ensuing activation of DNA damage response factors such as ATM play important but previously underappreciated roles in carcinogenesis and tumor growth. Furthermore, novel non-canonical roles of DNA repair factors such as ATM in tumor growth and treatment are also emerging. In this review, we try to summarize recent findings on this newly revealed link between DNA double strand break repair and cell death pathways.

中文翻译：

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有限的 MOMP、ATM 及其在致癌作用和癌症治疗中的作用。

有限的线粒体外膜通透性 (MOMP) 是一种新的生物学过程，在该过程中，哺乳动物细胞启动内在凋亡途径，线粒体通透性增加，但仍存活。有限 MOMP 的主要后果之一是凋亡核酸内切酶诱导的 DNA 双链断裂。最近的研究表明，这些 DNA 双链断裂和随后的 DNA 损伤反应因子（如 ATM）的激活在致癌作用和肿瘤生长中起着重要但以前未被充分认识的作用。此外，DNA 修复因子（如 ATM）在肿瘤生长和治疗中的新的非规范作用也正在出现。在这篇综述中，我们试图总结关于 DNA 双链断裂修复和细胞死亡途径之间这种新揭示的联系的最新发现。