The increasing sophistication of gene expression technologies has given rise to the idea that aging could be understood by analyzing transcriptomes. Mapping trajectories of gene expression changes in aging organisms, across different tissues and brain regions has provided insights on how biological functions change with age. However, recent publications suggest that transcriptional regulation itself deteriorates with age. Loss of transcriptional regulation will lead to non-regulated gene expression changes, but current analysis strategies were not designed to disentangle mixtures of regulated and non-regulated changes. Disentangling transcriptional data to distinguish adaptive, regulatory changes, from those that are the consequence of the age-associated deterioration is likely to create an analytical challenge but promises to unlock yet poorly understood aspects of many age-associated transcriptomes.

中文翻译：

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老化的转录组：字里行间阅读。

随着基因表达技术的日益复杂，人们认为可以通过分析转录组来理解衰老。绘制衰老生物体中不同组织和大脑区域中基因表达变化的轨迹，提供了有关生物功能如何随年龄变化的见解。然而，最近的出版物表明转录调控本身随着年龄的增长而恶化。转录调控的丧失将导致不受调控的基因表达变化，但目前的分析策略并非旨在解开受调控和不受调控的变化的混合物。解开转录数据以区分适应性、调节性变化，