Many plant NLR (nucleotide-binding, leucine-rich repeat) immune receptors require other NLRs for their function. In pairs of chromosomally adjacent sensor/helper NLRs, the sensor typically carries an integrated domain (ID) that mimics the authentic target of a pathogen effector. The RPW8-NLR clade supports the function of many diverse plant NLRs, particularly those with a TIR N-terminal domain, in concert with a family of EP-domain containing signalling partners. The NRC clade of NLRs are required for the function of many unlinked sensor NLRs in Solanaceous plants. We evaluate recent advances in paired NLR biology in the context of the structure and possible mechanisms of the first defined plant inflammasome containing ZAR1.

中文翻译：

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植物NLR在朋友的帮助下获得成功。

许多植物NLR（核苷酸结合，富含亮氨酸的重复序列）免疫受体都需要其他NLR才能发挥其功能。在成对的染色体上相邻的传感器/辅助NLR中，传感器通常带有一个集成域（ID），该域模仿病原体效应子的真实靶标。RPW8-NLR进化枝支持许多不同的植物NLR（特别是具有TIR N末端结构域的植物）的功能，与包含信号域的EP结构域家族协同工作。茄科植物中许多未链接的传感器NLR的功能需要NLR的NRC分支。我们在包含ZAR1的第一个定义的植物炎症小体的结构和可能机制的背景下，评估配对NLR生物学的最新进展。