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Prime time for primate functional genomics.
Current Opinion in Genetics & Development ( IF 3.7 ) Pub Date : 2020-06-13 , DOI: 10.1016/j.gde.2020.04.007
Genevieve Housman 1 , Yoav Gilad 2
Affiliation  

Functional genomics research is continually improving our understanding of genotype-phenotype relationships in humans, and comparative genomics perspectives can provide additional insight into the evolutionary histories of such relationships. To specifically identify conservation or species-specific divergence in humans, we must look to our closest extant evolutionary relatives. Primate functional genomics research has been steadily advancing and expanding, in spite of several limitations and challenges that this field faces. New technologies and cheaper sequencing provide a unique opportunity to enhance and expand primate comparative studies, and we outline possible paths going forward. The potential human-specific insights that can be gained from primate functional genomics research are substantial, and we propose that now is a prime time to expand such endeavors.

中文翻译:

灵长类功能基因组学的黄金时间。

功能基因组学研究不断提高我们对人类基因型-表型关系的理解,比较基因组学的观点可以提供对这种关系进化历史的更多见解。为了具体确定人类的保护性或物种特异性差异,我们必须寻找我们现存最接近的进化亲属。尽管该领域面临一些限制和挑战,但灵长类功能基因组学研究一直在稳步推进和扩展。新技术和更便宜的测序为加强和扩大灵长类动物比较研究提供了独特的机会,我们概述了可能的前进道路。可以从灵长类功能基因组学研究中获得的潜在的特定于人类的见解是巨大的,
更新日期:2020-06-13
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