Polycystic ovarian syndrome is a major factor contributing to the increasing incidence of infertility around the world. The metabolic effects of prolonged exposure to PCOS have been well determined from previous studies and seem to be detrimental in the long run. Studies have shown a multitude of conditions like insulin resistance, obesity and cardiovascular disorders to be associated with PCOS. This makes PCOS a syndrome requiring utmost attention in terms of women's health and reproduction. Interleukin-6 is one of the many cytokines released by adipocytes from fat deposits in the body. This review focuses on the Interleukin 6 signaling pathway and the data available on inflammatory modulators due to its significance PCOS mediated inflammation. There is noteworthy evidence of elevated IL-6 concentration in PCOS subjects that has been discussed in detail. The regulation of IL-6 levels in the body is in turn, maintained by a close relation with other cytokines, especially by a key regulator, NF-κB. Being involved in a multitude of other pathological conditions like rheumatoid arthritis, cardiovascular disorders, asthma, colon cancer and many more, the role of IL-6 is also investigated in PCOS in search of a probable reason for underlying inflammatory condition. On summarizing the IL-6 signaling pathway and therapeutic exploitation of the same, we see that IL-6 targeted drugs may be an efficient way of treating PCOS associated inflammation.

中文翻译：

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IL-6 信号在多囊卵巢综合征相关炎症中的作用。

多囊卵巢综合征是导致全球不孕症发病率上升的主要因素。之前的研究已经很好地确定了长期暴露于 PCOS 的代谢影响，并且从长远来看似乎是有害的。研究表明，胰岛素抵抗、肥胖和心血管疾病等多种疾病与 PCOS 相关。这使得 PCOS 成为一种在女性健康和生殖方面需要高度关注的综合征。白细胞介素 6 是脂肪细胞从体内脂肪沉积物中释放的众多细胞因子之一。本综述重点关注白细胞介素 6 信号通路和炎症调节剂的可用数据，因为其在 PCOS 介导的炎症中具有重要意义。已经详细讨论过的 PCOS 受试者中 IL-6 浓度升高的值得注意的证据。体内 IL-6 水平的调节反过来又由与其他细胞因子的密切关系维持，尤其是由关键调节因子 NF-κB 维持。IL-6 涉及多种其他病理状况，如类风湿性关节炎、心血管疾病、哮喘、结肠癌等，还在 PCOS 中研究了 IL-6 的作用，以寻找潜在炎症状况的可能原因。总结 IL-6 信号通路及其治疗开发，我们看到 IL-6 靶向药物可能是治疗 PCOS 相关炎症的有效方法。NF-κB。IL-6 涉及多种其他病理状况，如类风湿性关节炎、心血管疾病、哮喘、结肠癌等，还在 PCOS 中研究了 IL-6 的作用，以寻找潜在炎症状况的可能原因。总结 IL-6 信号通路及其治疗开发，我们看到 IL-6 靶向药物可能是治疗 PCOS 相关炎症的有效方法。NF-κB。IL-6 涉及多种其他病理状况，如类风湿性关节炎、心血管疾病、哮喘、结肠癌等，还在 PCOS 中研究了 IL-6 的作用，以寻找潜在炎症状况的可能原因。总结 IL-6 信号通路及其治疗开发，我们看到 IL-6 靶向药物可能是治疗 PCOS 相关炎症的有效方法。