Central nervous system function requires the proper formation and function of synapses. The α2δ auxiliary subunits of voltage-gated calcium channels have emerged as regulators of a number of critical events associated with regulation of synaptic function, including channel trafficking and localization, as well as the initial establishment of synaptic structures. In this review, we will discuss some of these recent studies which have uncovered novel mechanisms for α2δ function at the synapse, including the regulation of calcium channel α1 subunit specificity and the promotion of dendritic spine growth. Moreover, we will cover recent advances that have been made in understanding the consequences of aberrant α2δ signaling in injury and disease.

中文翻译：

---

α2δ 亚基在钙通道功能和突触连接中的新作用。

中枢神经系统功能需要突触的正确形成和功能。电压门控钙通道的 α2δ 辅助亚基已成为许多与突触功能调节相关的关键事件的调节剂，包括通道运输和定位，以及突触结构的初始建立。在这篇综述中，我们将讨论最近的一些研究，这些研究揭示了突触处 α2δ 功能的新机制，包括钙通道 α1 亚基特异性的调节和树突棘生长的促进。此外，我们将介绍在理解异常 α2δ 信号传导在损伤和疾病中的后果方面取得的最新进展。