Parkinson's disease (PD) is a common neurodegenerative disorder, with a continuously increasing prevalence. With improved clinical and therapeutic management of PD, more patients reach later stages of the disease, meaning they may face new clinical problems that were not commonly approached. This gave way to the description of a new PD stage, late-stage PD (LSPD), which is clinically discernible from the advanced-stage one. Therefore, LSPD patients have new and different needs, regarding pharmacological and non pharmacological interventions, including palliative care and multidisciplinary teams. LSPD patients constitute an'orphan population', who traditionally was excluded from previous studies, due to its high disability. With this manuscript, we intend to review specific management challenges of LSPD patients, covering this new concept and its clinical features, how to assess these patients, therapeutic recommendations, as well as discussing ongoing research and future perspectives.

中文翻译：

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晚期帕金森病管理中的挑战和前景。

帕金森病 (PD) 是一种常见的神经退行性疾病，患病率不断增加。随着 PD 临床和治疗管理的改进，更多的患者达到疾病的晚期，这意味着他们可能面临新的临床问题，而这些问题并不常见。这让位于一种新的 PD 阶段，即晚期 PD (LSPD)，它在临床上与晚期 PD 是可区分的。因此，LSPD 患者在药物和非药物干预方面有新的和不同的需求，包括姑息治疗和多学科团队。LSPD 患者构成了一个“孤儿群体”，由于其高残疾，他们传统上被排除在先前的研究之外。通过这份手稿，我们打算回顾 LSPD 患者的具体管理挑战，