Current Topics in Medicinal Chemistry ( IF 2.9 ) Pub Date : 2020-08-31 , DOI: 10.2174/1568026620666200622150325 Dan Xu 1 , Zhi Xu 1
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Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically active compounds. Indole alkaloids have the potential to exert anticancer activity via various antiproliferative mechanisms, and some of them, such as Vinblastine and Vincristinem, have already used in clinics or under clinical evaluations for the treatment of cancers. Therefore, indole alkaloids occupy an important position in the discovery of novel anticancer agents. This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship, and mechanisms of action covering the articles published from 2015 to 2020.
中文翻译：
具有潜在抗癌活性的吲哚生物碱。
自然界中丰富的吲哚生物碱是重要的药理活性化合物来源。吲哚生物碱具有通过多种抗增殖机制发挥抗癌活性的潜力，其中一些已在临床或临床评估中用于治疗癌症，例如长春碱和长春新碱。因此，吲哚生物碱在新型抗癌药的发现中占有重要地位。这篇综述着重介绍了吲哚生物碱作为潜在抗癌药的最新发展，它们的结构-活性关系以及作用机理，涵盖了2015年至2020年发表的文章。
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