Metabolic risk factors in children with kidney stone disease: an update.,Pediatric Nephrology

当前位置： X-MOL 学术 › Pediatr. Nephrol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Metabolic risk factors in children with kidney stone disease: an update.
Pediatric Nephrology ( IF 2.6 ) Pub Date : 2020-06-20 , DOI: 10.1007/s00467-020-04660-x
Francisco R Spivacow _{1,

2} , Elisa E Del Valle _{1,

2} , Juan A Boailchuk ₁ , Gaudencio Sandoval Díaz ₁ , Viridiana Rodríguez Ugarte ₁ , Zila Arreaga Álvarez ₁

Affiliation

Background

The prevalence of kidney stones in children has significantly increased in the past few decades, with concomitant increased morbidity and healthcare costs worldwide. Assessing metabolic risk factors is essential for diagnosis and specific treatment. The objective of this retrospective study is to identify the epidemiological and clinical characteristics of children under 17 years of age, as well as the metabolic risk factors of nephrolithiasis.

Methods

A total of 300 children with kidney stone disease were included to undergo several clinical tests using a standardized protocol.

Results

The mean age was 11.2 years, and the male:female ratio was 1.15:1.0. Biochemical abnormalities were found in 89.3% of all cases. A single urine metabolic risk factor was present in 52.6% (n = 141) of the patients, and multiple risk factors were present in 36.7% (n = 106). Idiopathic hypercalciuria (alone or in combination) and hypocitraturia (alone or in combination) were the most frequent risk factors identified in 47.0% and 39.6% of these patients, respectively. Renal colic and/or unspecified abdominal pain were the most frequent forms of presentation (76.9%), followed by hematuria in 64.4% with 97.5% of stones located in the upper urinary tract. A positive family history in first-degree and second-degree relatives was found in 64.8% of boys and 61.8% of girls.

Conclusions

We conclude that specific urinary metabolic risk factors can be found in most children with kidney stones, with hypercalciuria and hypocitraturia being the most common diagnoses.

中文翻译：

肾结石病患儿的代谢危险因素：最新情况。

背景

在过去的几十年中，儿童肾结石的患病率显着增加，随之而来的是全球范围内发病率和医疗费用的增加。评估代谢风险因素对于诊断和具体治疗至关重要。这项回顾性研究的目的是确定17岁以下儿童的流行病学和临床特征，以及肾结石的代谢危险因素。

方法

纳入研究的总共300名患有肾结石病的儿童接受了标准化协议的多项临床测试。

结果

平均年龄为11.2岁，男女比例为1.15：1.0。在所有病例中发现了89.3％的生化异常。52.6％（n = 141）的患者存在单一尿液代谢危险因素，而36.7％（n = 106）的患者存在多种危险因素。特发性高钙尿症（单独或合并）和低尿酸（单独或合并）是最常见的危险因素，分别在这些患者中占47.0％和39.6％。肾绞痛和/或未明确的腹痛是最常见的表现形式（76.9％），其次是血尿，占64.4％，其中97.5％的结石位于上尿路。在一级和二级亲属中有阳性家族史的男孩中有64.8％，女孩中有61.8％。