Background

Children who experience more than one urinary tract infection (UTI) are at increased risk of kidney scarring due to their UTIs. Girls are at especially high risk for developing kidney scarring as a result of recurrent UTIs. Prior work suggested that neutrophil gelatinase-associated lipocalin (NGAL) may be lower in children with recurrent UTI compared with those without. The objective of this work was to compare urine NGAL concentrations in matched urine samples in girls with single and recurrent UTIs.

Methods

Girls less than 6 years of age who presented with signs and symptoms of a UTI were eligible for enrollment. Both acute, obtained from residual urine collected as part of their clinical evaluation, and follow-up urine samples, obtained after the completion of antibiotics when the patient was in their usual state of health, were collected from patients. Acute and follow-up urine NGAL concentrations were compared between girls with single and recurrent UTIs, as well as those with negative cultures who served as controls.

Results

Seventy girls were included in this study, 6 controls, 43 single UTIs, and 20 girls with recurrent UTIs. Patients in the control group had lower median acute NGAL concentrations than either those with single or recurrent UTI. There were no differences in either acute or follow-up urine NGAL concentrations between those with single and recurrent UTIs.

Conclusion

In this cohort of girls less than 6 years of age, there is no difference in urine NGAL concentrations between those with single and recurrent UTIs.

中文翻译：

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患有尿路反复感染的女孩的尿中性粒细胞明胶酶相关的脂蛋白。

背景

患有一种以上尿路感染（UTI）的儿童由于其泌尿道感染而增加肾脏结疤的风险。由于尿路感染反复发作，女孩患肾脏瘢痕形成的风险特别高。先前的研究表明，复发性UTI患儿的中性粒细胞明胶酶相关脂钙蛋白（NGAL）可能低于非复发性UTI患儿。这项工作的目的是比较单次和多次尿路感染的女孩在匹配尿液样本中尿液中的NGAL浓度。

方法

年龄小于6岁且出现UTI体征和症状的女孩符合入学条件。从患者的临床评估中收集了从残留尿液中收集的急性尿液，以及在患者处于正常健康状态后抗生素用完后获得的后续尿液样本。比较了单次和多次尿路感染的女孩，以及以阴性培养作为对照的女孩的急性和随访尿NGAL浓度。

结果

这项研究包括70名女孩，6名对照，43名单尿路感染和20名复发性尿路感染的女孩。对照组患者的急性NGAL浓度中位数低于单次或复发性UTI患者。单一或复发性UTI者的急性或随访尿NGAL浓度无差异。

结论

在这个年龄小于6岁的女孩队列中，单次和多次UTI的尿NGAL浓度没有差异。