Interleukin-6 (IL-6) is a pleotropic cytokine, and in this review, we highlight recent studies focusing on the role of IL-6 in health and disease. IL-6 is known as an exercise-inducible myokine, and in rodents it was identified that a lactate-dependent increase in protease activity mediates IL-6 release from skeletal muscle, which acts in both an autocrine and paracrine roles. In humans, a series of publications observed that blocking IL-6 during exercise training prevented beneficial adaptations, such as reductions in visceral and epicardial fat mass. Independent of exercise, IL-6 impacts postprandial physiology, as demonstrated by a slowing of gastric emptying rate and improving glucose homeostasis. Finally, an engineered cytokine harnessing the biology of IL-6, termed IC7Fc, was found to have beneficial impacts on numerous health outcomes. Together, these recent advances indicate that IL-6 has a multifaceted, and perhaps beneficial, role in health and disease.

中文翻译：

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白细胞介素 6 在健康和疾病中的作用的最新进展。

白细胞介素 6 (IL-6) 是一种多效性细胞因子，在本综述中，我们重点介绍了近期关于 IL-6 在健康和疾病中的作用的研究。IL-6 被称为运动诱导的肌因子，在啮齿类动物中，已经发现蛋白酶活性的乳酸依赖性增加介导了骨骼肌中 IL-6 的释放，其具有自分泌和旁分泌两种作用。在人类中，一系列出版物观察到在运动训练期间阻断 IL-6 会阻止有益的适应，例如减少内脏和心外膜脂肪量。与运动无关，IL-6 会影响餐后生理机能，如胃排空速度减慢和葡萄糖稳态改善所证明的那样。最后，发现一种利用 IL-6 生物学的工程细胞因子，称为 IC7Fc，对许多健康结果具有有益影响。